Abstract | BACKGROUND: Blockade of the renin-angiotensin system (RAS) is well documented to be renoprotective; however, not all patients with glomerulonephritis respond well to this therapy. The interindividual variation in response to the RAS blockade may be in part genetically determined, whereas the results have been controversial. METHODS: RESULTS: CONCLUSION: This study provides evidence that the M235T and A(-20)C genotype of AGT can influence the therapeutic efficacy of a RAS blockade on the renal survival in IgAN.
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Authors | Ichiei Narita, Shin Goto, Noriko Saito, Jin Song, Kentaro Omori, Daisuke Kondo, Minoru Sakatsume, Fumitake Gejyo |
Journal | Kidney international
(Kidney Int)
Vol. 64
Issue 3
Pg. 1050-8
(Sep 2003)
ISSN: 0085-2538 [Print] United States |
PMID | 12911556
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Angiotensin Receptor Antagonists
- Angiotensin-Converting Enzyme Inhibitors
- Angiotensinogen
- Threonine
- Guanine
- Methionine
- Adenine
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Topics |
- Adenine
- Adult
- Alleles
- Angiotensin Receptor Antagonists
- Angiotensin-Converting Enzyme Inhibitors
(therapeutic use)
- Angiotensinogen
(genetics)
- Cytoprotection
- Female
- Gene Frequency
- Genetic Variation
- Genotype
- Glomerulonephritis, IGA
(complications, genetics, physiopathology)
- Guanine
- Haplotypes
- Humans
- Kidney
(physiopathology)
- Kidney Diseases
(etiology)
- Male
- Methionine
(genetics)
- Middle Aged
- Polymorphism, Genetic
(genetics)
- Renin-Angiotensin System
(drug effects)
- Risk Factors
- Threonine
(genetics)
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