Abstract | OBJECTIVE: DESIGN: Observational study. Academic medical center. PATIENT(S): INTERVENTION(S): None.[1] The proportion of NK cells in the total lymphocyte population, [2] the concentration of NK cells per microliter of blood, and [3] NK activity (NKA), using both standard and whole-blood assays. RESULT(S): Primary aborters had the highest proportion and concentration of NK cells and had the highest activity using the standard assay. Secondary aborters had an intermediate level of these NK cell indices, whereas the control patients had the lowest levels. Using the whole-blood NKA assay, the differences between primary and secondary aborters were most apparent: primary aborters had significantly higher NKA than did either secondary aborters or control women (72, 40, and 35 lytic units, respectively). Approximately 50% of the variability in NKA could be attributed to differences in concentrations of NK cell per microliter of blood. CONCLUSION(S):
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Authors | Keren Shakhar, Shamgar Ben-Eliyahu, Ron Loewenthal, Ella Rosenne, Howard Carp |
Journal | Fertility and sterility
(Fertil Steril)
Vol. 80
Issue 2
Pg. 368-75
(Aug 2003)
ISSN: 0015-0282 [Print] United States |
PMID | 12909501
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
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Topics |
- Abortion, Habitual
(classification, pathology)
- Blood Cells
(pathology)
- Case-Control Studies
- Female
- Humans
- Incidence
- Infant, Newborn
- Killer Cells, Natural
(pathology)
- Lymphocyte Count
- Maternal Age
- Thrombophilia
(complications, epidemiology)
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