Abstract |
Seventy-nine patients with cutaneous leishmaniasis were included in this study. The experimental group (n = 38) was treated with pentamidine isothionate in a dose of 4mg/kg/day on alternate days, for one week. The control group (n = 41) was treated with N- methylglucamine in a dose of 20mgSbV/kg/day for 20 days. Twenty-one isolates were identified using monoclonal antibody technique. We characterized Leishmania (Viannia) braziliensis, most frequently. There was a cure rate of 71.05% of the patients in the experimental group and 73.17% in the control group (p = 0.47). We found a statistical significance regarding frequency of ECG alterations between the experimental and control group (p<0.05). In our study pentamidine was as effective as antimonial for the treatment of american cutaneous leishmaniasis. It proved to be a safer drug considering heart toxicity. Moreover, it requires less time to complete the treatment.
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Authors | Carmen Déa Ribeiro de Paula, João Herman Duarte Sampaio, Danielle Rizzo Cardoso, Raimunda Nonata Ribeiro Sampaio |
Journal | Revista da Sociedade Brasileira de Medicina Tropical
(Rev Soc Bras Med Trop)
2003 May-Jun
Vol. 36
Issue 3
Pg. 365-71
ISSN: 0037-8682 [Print] Brazil |
Vernacular Title | Estudo comparativo da efic cia de isotionato de pentamidina administrada em tr s doses durante uma semana e de N-metil-glucamina 20mgSbV/kg/dia durante 20 dias para o tratamento da forma cut nea da leishmaniose tegumentar americana. |
PMID | 12908038
(Publication Type: Clinical Trial, Comparative Study, Controlled Clinical Trial, Journal Article)
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Chemical References |
- Antiprotozoal Agents
- Organometallic Compounds
- Pentamidine
- Meglumine
- Meglumine Antimoniate
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Topics |
- Adult
- Animals
- Antiprotozoal Agents
(administration & dosage, adverse effects, economics)
- Electrocardiography
- Follow-Up Studies
- Humans
- Leishmaniasis, Cutaneous
(drug therapy)
- Meglumine
(administration & dosage, adverse effects, economics)
- Meglumine Antimoniate
- Organometallic Compounds
(administration & dosage, adverse effects, economics)
- Pentamidine
(administration & dosage, adverse effects, economics)
- Prospective Studies
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