HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Recombinant factor VIIa: a universal hemostatic agent?

Abstract
Recombinant factor VIIa (rVIIa) has proved effective for the treatment and prevention of hemorrhage in patients with inherited hemophilia A and B who develop inhibitors to factor VIII or IX, and patients with acquired hemophilia A. More recently, there is evidence that rVIIa may also be effective in the control of abnormal bleeding in a variety of other conditions, such as inherited factor VII deficiency, thrombocytopenia, Glanzmann's thrombasthenia, and liver disease. In some of the reports, rVIIa appeared to be effective in controlling massive hemorrhage in which there was no response to conventional measures. It is now considered by some to be potentially the first universal hemostatic agent. However, further prospective, controlled, and adequately powered clinical studies are clearly required. It will be of particular interest to determine the efficacy of rVIIa in conditions such as severe thrombocytopenia, severe von Willebrand disease, severe defects in platelet activation, and severe deficiencies of factors V, X, II, and fibrinogen in which effectiveness would seem to be unlikely based on our current understanding of mechanisms of action of rVIIa.
AuthorsJohn V Lloyd, J Heinrich Joist
JournalCurrent hematology reports (Curr Hematol Rep) Vol. 1 Issue 1 Pg. 19-26 (Sep 2002) ISSN: 1540-3408 [Print] United States
PMID12901121 (Publication Type: Journal Article, Review)
Chemical References
  • Hemostatics
  • Recombinant Proteins
  • Factor VIIa
Topics
  • Factor VIIa (adverse effects, pharmacokinetics, therapeutic use)
  • Hemorrhage (drug therapy, etiology, prevention & control)
  • Hemostatics (therapeutic use)
  • Humans
  • Recombinant Proteins

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: