Gene amplification and splice variants of 25-hydroxyvitamin D3 1,alpha-hydroxylase (CYP27B1) in glioblastoma multiforme--a possible role in tumor progression?

Abstract

We report a gene amplification of 25-hydroxyvitamin D3 1,alpha-hydroxylase and the appearance of various splice variants in glioblastoma multiforme. Some protein products of the widespread expressed variants may exert a biological function. The analysis of amplification and overexpression of alternative transcripts will provide new insights in the regulation of the 25-hydroxyvitamin D3 1,alpha-hydroxylase expression and may have implications for prognosis in glioblastoma.

• Authors: Britta Diesel, Ulrike Fischer, Eckart Meese
• Journal: Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer (Recent Results Cancer Res) Vol. 164 Pg. 151-5 ( 2003) ISSN: 0080-0015 [Print] Germany
• PMID: 12899520 (Publication Type: Journal Article, Review)

Chemical References

• 25-Hydroxyvitamin D3 1-alpha-Hydroxylase

Topics

• 25-Hydroxyvitamin D3 1-alpha-Hydroxylase (genetics, metabolism)
• Alternative Splicing
• Brain Neoplasms (enzymology, metabolism)
• Gene Amplification
• Glioblastoma (enzymology, genetics, metabolism)
• Humans