Granular lymphocyte proliferative disorder after autologous peripheral blood stem cell transplantation for multiple myeloma.

Abstract

A 57-yr-old woman with multiple myeloma underwent tandem autologous peripheral blood stem cell transplantation (APBSCT). Fever, anemia, and thrombocytopenia, followed by the proliferation of granular lymphocytes in the peripheral blood occurred, after a second APBSCT. Clonal rearrangement of the T-cell receptor was detected using Southern blot analysis of peripheral blood samples. Granular lymphocyte proliferative disorders (GLPD) were diagnosed. After steroid therapy, the symptoms resolved. Lymphocytosis did not recur after the discontinuation of steroids. There have been a few reports of GLPD after solid organ and allogeneic hematopoietic stem cell transplantations. We report a first case of GLPD after APBSCT.

• Authors: K Kawakubo, T Endo, K Koizumi, M Nishio, K Fujimoto, T Sakai, K Sawada, T Koike
• Journal: European journal of haematology (Eur J Haematol) Vol. 71 Issue 2 Pg. 124-7 (Aug 2003) ISSN: 0902-4441 [Print] England
• PMID: 12890152 (Publication Type: Case Reports, Journal Article)

Chemical References

• Steroids

Topics

• Clone Cells (pathology)
• Female
• Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor
• Humans
• Lymphoproliferative Disorders (drug therapy, etiology, pathology)
• Middle Aged
• Multiple Myeloma (complications, therapy)
• Peripheral Blood Stem Cell Transplantation (adverse effects)
• Steroids (therapeutic use)
• Transplantation, Autologous