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[The mechanism of the action of dalargin in experimental myocardial ischemia].

Abstract
In acute experiments on cats it has been shown that dalargin possess antiarrhythmic affect in myocardial ischemia. Antiarrythmic effect of dalagrig may be connected both with reflex and with direct action of dalargin on neurons structure, which
AuthorsS D Mikhaĭlova, G I Storozhakov, N A Bebiakova, N V Glushchenko, T M Semushkina
JournalBiulleten' eksperimental'noi biologii i meditsiny (Biull Eksp Biol Med) Vol. 114 Issue 10 Pg. 345-7 (Oct 1992) ISSN: 0365-9615 [Print] Russia (Federation)
Vernacular TitleMekhanizm deĭstviia dalargina pri éksperimental'noĭ ishemii miokarda.
PMID1288681 (Publication Type: Comparative Study, Journal Article)
Chemical References
  • Anti-Arrhythmia Agents
  • Enkephalin, Leucine-2-Alanine
  • enkephalin-Leu, Ala(2)-Arg(6)-
Topics
  • Animals
  • Anti-Arrhythmia Agents (pharmacology, therapeutic use)
  • Cats
  • Disease Models, Animal
  • Dose-Response Relationship, Drug
  • Drug Evaluation, Preclinical
  • Enkephalin, Leucine-2-Alanine (analogs & derivatives, pharmacology, therapeutic use)
  • Female
  • Heart (drug effects, innervation, physiopathology)
  • Heart Rate (drug effects, physiology)
  • Male
  • Myocardial Ischemia (complications, drug therapy, etiology, physiopathology)
  • Vagotomy
  • Ventricular Fibrillation (drug therapy, etiology, physiopathology)

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