Higher plasma 5-hydroxyindoleacetic acid levels are associated with SSRI-induced nausea.

Abstract

We investigated the association between selective serotonin reuptake inhibitors (SSRIs; paroxetine or fluvoxamine) and nausea with regard to plasma 5-hydroxyindoleacetic acid (p5-HIAA) levels. Forty-eight patients meeting the DSM-IV criteria for major depressive disorder and treated with paroxetine or fluvoxamine participated in this study. p5-HIAA levels after SSRI administration were significantly higher in the nausea group than those in the nonnausea group (nausea group: 8.0 +/- 4.6 ng/ml; nonnausea group: 3.6 +/- 2.2 ng/ml; p < 0.01). On the other hand, no significant difference was found between the nausea and nonnausea group in terms of p5-HIAA levels before each drug administration. These results suggest that SSRI-induced nausea is associated with serotonergic hyperactivity in the gastrointestinal tract.

• Authors: Nobuhisa Ueda, Reiji Yoshimura, Koji Shinkai, Yumi Sakata, Jun Nakamura
• Journal: Neuropsychobiology (Neuropsychobiology) Vol. 48 Issue 1 Pg. 31-4 ( 2003) ISSN: 0302-282X [Print] Switzerland
• PMID: 12886038 (Publication Type: Comparative Study, Journal Article)
• Copyright: Copyright 2003 S. Karger AG, Basel

Chemical References

• Acetophenones
• Indoles
• Oximes
• Serotonin Uptake Inhibitors
• Paroxetine
• indole-3-lactic acid
• fluxofenim

Topics

• Acetophenones (adverse effects, therapeutic use)
• Adult
• Aged
• Depressive Disorder (blood, drug therapy, physiopathology)
• Diagnostic and Statistical Manual of Mental Disorders
• Female
• Humans
• Indoles (blood)
• Male
• Middle Aged
• Nausea (blood, chemically induced)
• Oximes (adverse effects, therapeutic use)
• Paroxetine (adverse effects, therapeutic use)
• Selective Serotonin Reuptake Inhibitors (adverse effects, therapeutic use)