Abstract | OBJECTIVE: METHODS: Expression of survivin gene was evaluated by reverse transcription polymerase chain reaction (RT-PCR) in 35 cases of epithelial ovarian cancer, and compared with that in 10 cases of borderline cancer, 10 cases of benign tumors and 10 cases of normal tissue. Expression of bcl-2 and bax was detected by immunohistochemistry streptomycin- avidin- biotin- peroxidase complex (SABC) method, and correlation between them was analyzed. RESULTS: CONCLUSION:
survivin gene may play an important role in pathogenesis of ovarian cancer, apoptosis related gene bcl-2 may have a synergic role and bax have an antagonistic role with survivin gene in formation and progression of ovarian cancer.
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Authors | Shu-lan Zhang, Chang-qing Zhao, Bei Lin, Yan Li, Hong Gao |
Journal | Zhonghua fu chan ke za zhi
(Zhonghua Fu Chan Ke Za Zhi)
Vol. 38
Issue 4
Pg. 203-6
(Apr 2003)
ISSN: 0529-567X [Print] China |
PMID | 12885364
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- BAX protein, human
- BIRC5 protein, human
- Inhibitor of Apoptosis Proteins
- Microtubule-Associated Proteins
- Neoplasm Proteins
- Proto-Oncogene Proteins c-bcl-2
- Survivin
- bcl-2-Associated X Protein
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Topics |
- Adolescent
- Adult
- Aged
- Apoptosis
(genetics)
- Female
- Humans
- Inhibitor of Apoptosis Proteins
- Microtubule-Associated Proteins
(biosynthesis, genetics)
- Middle Aged
- Neoplasm Proteins
- Ovarian Neoplasms
(genetics, metabolism, pathology)
- Proto-Oncogene Proteins c-bcl-2
(biosynthesis)
- Reverse Transcriptase Polymerase Chain Reaction
- Survivin
- bcl-2-Associated X Protein
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