[Clinical features of patients associated with anti-GM1b antibody].

Abstract

To clarify the clinical features of patients with anti-GM1b antibody, we retrospectively investigated which conditions were associated with anti-GM1b antibody in a large number of patients. Two hundred out of 1,713 patients had anti-GM1b antibody. One hundred and sixty-six (83%) were diagnosed with Guillain-Barré syndrome (GBS) or atypical GBS with preserved deep tendon reflexes. Our study suggests that the anti-GM1b antibody testing is useful for supporting the diagnosis of GBS. In addition, anti-GM1b antibody was detected in 18 patients with Fisher syndrome and the related conditions associated with anti-GQ1b IgG antibody, and 3 patients with ataxic GBS associated with anti-GD1b IgG antibody.

• Authors: Muneto Tatsumoto, Nobuhiro Yuki, Masaaki Odaka, Koichi Hirata
• Journal: Rinsho shinkeigaku = Clinical neurology (Rinsho Shinkeigaku) Vol. 43 Issue 4 Pg. 149-53 (Apr 2003) ISSN: 0009-918X [Print] Japan
• PMID: 12884824 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Autoantibodies
• Biomarkers
• Immunoglobulin G
• Immunoglobulin M
• G(M1) Ganglioside
• ganglioside M1b

Topics

• Adult
• Aged
• Autoantibodies (blood)
• Biomarkers (blood)
• Female
• G(M1) Ganglioside (analogs & derivatives, immunology)
• Guillain-Barre Syndrome (classification, diagnosis, physiopathology)
• Humans
• Immunoglobulin G (blood)
• Immunoglobulin M (blood)
• Male
• Miller Fisher Syndrome (diagnosis, physiopathology)
• Retrospective Studies