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Nm23-H1 expression does not predict clinical survival in colorectal cancer patients.

Abstract
The gene Nm23, which encodes for a nucleoside diphosphate kinase, has been defined as a metastasis-suppressor gene because of the inverse correlation between its expression and the metastatic capacity of the tumor cells. For colorectal cancer, however, the findings are equivocal. The aim of our study was to assess, in 160 patients undergoing surgery for colorectal cancer (CRC), the expression of the Nm23-H1 protein and to evaluate its possible associations with traditional clinicopathologic variables, with DNA-ploidy and proliferative activity (S-phase fraction, SPF), and with disease-free and overall survival of patients. Nm23-H1 expressions were evaluated on paraffin-embedded tissue by immunohistochemistry; DNA-ploidy and SPF on frozen tissue by flow-cytometric analysis. The median follow-up time in our study group was 71 months (range 34-115 months). No association was observed between Nm23-H1 protein expression and clinicopathological variables, S-phase fraction and DNA-ploidy. Furthermore, no significant differences were observed in the survival of patients with either moderate or strong Nm23-H1 expression. The major significant predictors for both disease relapse and death were advanced Dukes' stage, DNA aneuploid tumors and high SPF, while lymphohematic invasion was the only independent factor for relapse and non-curative resection for death. Our results indicate that Nm23-H1 activity is tissue-specific and that in CRCs the expression of the protein is not associated with tumor progression and patient prognosis, although further studies are required in order to throw more light on the possible clinical significance of the overexpression of the protein Nm23-H1 in such tumors.
AuthorsLuisa Dusonchet, Simona Corsale, Manuela Migliavacca, Valentina Calò, Viviana Bazan, Antonella Amato, Patrizia Cammareri, Maria Serena Totaro, Valentina Agnese, Sandra Cascio, Gaspare La Rocca, Pasqua Sandra Sisto, Gabriella Dardanoni, Maria Rosaria Valerio, Nello Grassi, Stefania Latteri, Massimo Cajozzo, Maria Buscemi, Sergio Castorina, Vincenza Morello, Rosa Maria Tomasino, Nicola Gebbia, Antonio Russo
JournalOncology reports (Oncol Rep) 2003 Sep-Oct Vol. 10 Issue 5 Pg. 1257-63 ISSN: 1021-335X [Print] Greece
PMID12883690 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • NM23 Nucleoside Diphosphate Kinases
  • NME1 protein, human
  • Nucleoside-Diphosphate Kinase
Topics
  • Cell Division
  • Colorectal Neoplasms (metabolism, mortality)
  • Cytoplasm (metabolism)
  • Disease Progression
  • Disease-Free Survival
  • Exons
  • Flow Cytometry
  • Humans
  • Immunohistochemistry
  • Models, Genetic
  • NM23 Nucleoside Diphosphate Kinases
  • Nucleoside-Diphosphate Kinase
  • Ploidies
  • Prognosis
  • Protein Biosynthesis
  • S Phase
  • Time Factors

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