A 27 years old woman was admitted due to
abdominal cramps,
jaundice and oligoanuria, starting 48 hours after eating Chinese food. Hepatic biochemical tests, abdominal ultrasound and retrograde pyelography were normal. The urine was intensely orange colored and microscopic analysis was normal. The serum
creatinine and
urea nitrogen on admission were 4.59 and 42.5 mg/dl and rose to 13.5 and 72.4 mg/dl, respectively, at the 6th hospital day.
Oliguria lasted only 48 hours. Dialysis was not used, since the patient was in good general condition and uremic symptoms were absent. On the 7th day,
azotemia began to subside and at the 14th day, serum
creatinine was 1.0 mg/dl. Before hospital discharge, she confessed the ingestion of 2.000 mg of
phenazopyridine, during a nervous breakdown, aiming to sleep deeply. Remarkable was the persistence of the orange color of her urine during several days and the dissociation between the rate of increase of serum
creatinine with respect to
urea nitrogen. This is an unusual case of
acute renal failure caused by an overdose of a
drug, commonly prescribed for
urinary tract infections.