[Polymorphism of the sulfonylurea receptor gene in type 2 diabetes mellitus].

Abstract

Sulfonylureas are used in treatment of diabetes. Resistance to these derivatives is a therapeutical problem. Sulfonylureas act through sulfonylurea receptor 1 (SUR1) in the beta cell. SUR1 also enhances a physiological secretion of insulin induced by an increase of glucose concentration. It may be expected that polymorphism of SUR1 gene can lead to beta cell dysfunction and resistance to sulfonylureas. The aim of this study was to examine the frequency of polymorphism in exon 22 of SUR1 gene and its correlation with type 2 diabetes mellitus and sulfonylurea treatment failure. The group consisted of 42 patients with type 2 diabetes. The controls were 46 persons with proper glucose tolerance. Polymorphism was found in 5 patients and in 1 control person. Neither statistically significant difference of polymorphism frequency nor correlation between polymorphism and sulfonylurea failure was found due to a low number of cases. Polymorphism of exon 22 of SUR1 gene appeared more frequent in diabetic than in non-diabetic subjects but this was statistically not significant.

• Authors: Maciej Owecki, Wanda Horst-Sikorska, Marta Kaczmarek, Ryszard Słomski, Jerzy Sowiński
• Journal: Polskie Archiwum Medycyny Wewnetrznej (Pol Arch Med Wewn) Vol. 109 Issue 2 Pg. 143-8 (Feb 2003) Poland
• Vernacular Title: Polimorfizm eksonu 22 genu receptora dla sulfonylomocznika w cukrzycy typu 2.
• PMID: 12879777 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• ABCC8 protein, human
• ATP-Binding Cassette Transporters
• Potassium Channels
• Potassium Channels, Inwardly Rectifying
• Receptors, Drug
• Sulfonylurea Compounds
• Sulfonylurea Receptors

Topics

• ATP-Binding Cassette Transporters
• Diabetes Mellitus, Type 2 (drug therapy, genetics)
• Female
• Humans
• Male
• Middle Aged
• Polymorphism, Genetic (genetics)
• Potassium Channels (genetics)
• Potassium Channels, Inwardly Rectifying
• Receptors, Drug (genetics)
• Sulfonylurea Compounds (therapeutic use)
• Sulfonylurea Receptors