Efficacy of single-dose azithromycin in treatment of acute otitis media in children after a baseline tympanocentesis.

Abstract

Children with acute otitis media underwent tympanocentesis and were given a single dose of 30 mg of azithromycin/kg of body weight. At day 28, the overall clinical cure rate was 206 of 242 (85%). Clinical cure rates for patients infected with Streptococcus pneumoniae (67 of 76; 88%) and Haemophilus influenzae (28 of 44; 64%) were consistent with historical rates for the 5-day dosing regimen.

• Authors: Michael W Dunne, Chandra Khurana, Adriano Arguedas Mohs, Adib Rodriguez, Antonio Arrieta, Samuel McLinn, Judy A Krogstad, Mark Blatter, Richard Schwartz, Sergio L Vargas, Paz Emparanza, Pilar Fernandez, Willis M Gooch 3rd, Mary Aspin, John Podgore, Irmeli Roine, Jeffrey L Blumer, Garth D Ehrlich, Jean Chow
• Journal: Antimicrobial agents and chemotherapy (Antimicrob Agents Chemother) Vol. 47 Issue 8 Pg. 2663-5 (Aug 2003) ISSN: 0066-4804 [Print] United States
• PMID: 12878537 (Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Bacterial Agents
• Azithromycin

Topics

• Anti-Bacterial Agents (administration & dosage, therapeutic use)
• Azithromycin (administration & dosage, therapeutic use)
• Child, Preschool
• Combined Modality Therapy
• Drainage
• Female
• Humans
• Infant
• Male
• Otitis Media (drug therapy, microbiology, therapy)