Abstract | BACKGROUND/AIMS: The most rational treatment of moderate ascites is spironolactone alone or in combination with furosemide. However, it is unknown which of these two treatment schedules is preferable. METHODS: RESULTS: The response rate (98% in Group 1 vs. 94% in Group 2), the rapidity of ascites mobilization and the incidence of complications induced by diuretic therapy was similar in both groups. The need to reduce the diuretic dosage was significantly higher in Group 1 than Group 2 (68% vs. 34%; P=0.002). CONCLUSIONS:
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Authors | Justiniano Santos, Ramon Planas, Albert Pardo, Rosa Durández, Eduard Cabré, Rosa Maria Morillas, Maria Luisa Granada, José Angel Jiménez, Enrique Quintero, Miquel Angel Gassull |
Journal | Journal of hepatology
(J Hepatol)
Vol. 39
Issue 2
Pg. 187-92
(Aug 2003)
ISSN: 0168-8278 [Print] Netherlands |
PMID | 12873814
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Diuretics
- Spironolactone
- Furosemide
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Topics |
- Aged
- Ascites
(drug therapy, etiology)
- Diuretics
(administration & dosage, adverse effects)
- Drug Therapy, Combination
- Female
- Furosemide
(administration & dosage, adverse effects)
- Humans
- Liver Cirrhosis
(complications)
- Male
- Middle Aged
- Spironolactone
(administration & dosage, adverse effects)
- Treatment Outcome
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