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EBER-1 positive diffuse large cell lymphoma presenting as lupus nephritis.

Abstract
Approximately one-third of membranous glomerulonephritis (MGN) cases in adults are associated with systemic diseases, including systemic lupus erythematosus (SLE) or malignancies. Malignancy-associated glomerulonephritis is rarely found in non-Hodgkin's lymphoma (NHL). Epstein-Barr virus (EBV) has been postulated to contribute to the pathogenesis of both SLE and NHL. We described a 37-year-old woman with nephrotic syndrome who presented with clinical features of SLE and renal-biopsy revealed lupus MGN. The patient also suffered from concomitant progressive lymphadenopathy and NHL (diffuse large B-cell type) was demonstrated by neck lymph node biopsy. Serologic studies demonstrated EBV infection and specific EBV antigens were present on lymph node and metastatic sites. We offer a discussion regarding the complex relationships between SLE, NHL, MGN and EBV.
AuthorsMing-Hsien Lin, Jeng-Jong Huang, Tsai-Yun Chen, Fen-Fen Chen, Kong-Chao Chang, Ming-Fei Liu, Wen-Tsung Huang, Wu-Chou Su, Chao-Jung Tsao
JournalLupus (Lupus) Vol. 12 Issue 6 Pg. 486-9 ( 2003) ISSN: 0961-2033 [Print] England
PMID12873053 (Publication Type: Case Reports, Journal Article)
Topics
  • Acute Kidney Injury
  • Adult
  • Biopsy, Needle
  • Diagnosis, Differential
  • Disease Progression
  • Epstein-Barr Virus Infections (diagnosis)
  • Fatal Outcome
  • Female
  • Glomerulonephritis, Membranous (diagnosis, pathology)
  • Herpesvirus 4, Human (isolation & purification)
  • Humans
  • Immunohistochemistry
  • Lupus Nephritis (diagnosis, pathology)
  • Lymphoma, Large B-Cell, Diffuse (diagnosis, pathology)
  • Risk Factors

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