Abstract |
Approximately one-third of membranous glomerulonephritis (MGN) cases in adults are associated with systemic diseases, including systemic lupus erythematosus (SLE) or malignancies. Malignancy-associated glomerulonephritis is rarely found in non-Hodgkin's lymphoma (NHL). Epstein-Barr virus (EBV) has been postulated to contribute to the pathogenesis of both SLE and NHL. We described a 37-year-old woman with nephrotic syndrome who presented with clinical features of SLE and renal-biopsy revealed lupus MGN. The patient also suffered from concomitant progressive lymphadenopathy and NHL (diffuse large B-cell type) was demonstrated by neck lymph node biopsy. Serologic studies demonstrated EBV infection and specific EBV antigens were present on lymph node and metastatic sites. We offer a discussion regarding the complex relationships between SLE, NHL, MGN and EBV.
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Authors | Ming-Hsien Lin, Jeng-Jong Huang, Tsai-Yun Chen, Fen-Fen Chen, Kong-Chao Chang, Ming-Fei Liu, Wen-Tsung Huang, Wu-Chou Su, Chao-Jung Tsao |
Journal | Lupus
(Lupus)
Vol. 12
Issue 6
Pg. 486-9
( 2003)
ISSN: 0961-2033 [Print] England |
PMID | 12873053
(Publication Type: Case Reports, Journal Article)
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Topics |
- Acute Kidney Injury
- Adult
- Biopsy, Needle
- Diagnosis, Differential
- Disease Progression
- Epstein-Barr Virus Infections
(diagnosis)
- Fatal Outcome
- Female
- Glomerulonephritis, Membranous
(diagnosis, pathology)
- Herpesvirus 4, Human
(isolation & purification)
- Humans
- Immunohistochemistry
- Lupus Nephritis
(diagnosis, pathology)
- Lymphoma, Large B-Cell, Diffuse
(diagnosis, pathology)
- Risk Factors
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