[Matricryptins derived from non fibrillar collagens, MMP-2 and SPARC are involved in the control of angiogenesis].

Abstract

The name matricryptin was proposed by Davis et al. (2000) for enzymatic fragments of extracellular matrix containing exposed matricryptic sites. The exposure of these sites occurred after structural or conformational modifications. Matricryptins derived from non fibrillar collagens (IV, VIII, XV and XVIII) and from matrix metalloproteinase-2 inhibit angiogenesis and tumor growth. Proteolysis of SPARC releases several peptides which exert opposite effects on angiogenesis. Matricryptins derived from glycosaminoglycans also participate in the control of angiogenesis.

• Authors: Sylvie Ricard-Blum
• Journal: Journal de la Societe de biologie (J Soc Biol) Vol. 197 Issue 1 Pg. 41-4 ( 2003) ISSN: 1295-0661 [Print] France
• Vernacular Title: Implication des matricryptines issues des collagènes non fibrillaires, de MMP-2 et de SPARC dans le contrôle de l'angiogenèse.
• PMID: 12868265 (Publication Type: English Abstract, Journal Article)

Chemical References

• Non-Fibrillar Collagens
• Osteonectin
• Matrix Metalloproteinase 2

Topics

• Binding Sites
• Extracellular Matrix (chemistry, metabolism)
• Humans
• Matrix Metalloproteinase 2 (metabolism)
• Neovascularization, Physiologic
• Non-Fibrillar Collagens (metabolism)
• Osteonectin (metabolism)