Determination and use of haplotypes: ethnic comparison and association of the lipoprotein lipase gene and coronary artery disease in Mexican-Americans.

Abstract

PURPOSE:

To illustrate an approach of deriving haplotypes for genetic association studies, using the lipoprotein lipase (LPL) gene and coronary artery disease.

METHODS:

Six polymorphisms sufficient to distinguish the most common haplotypes in the 3' end of LPL were identified by genotyping 10 polymorphisms in a small pilot population. These were used to haplotype LPL in large family samples of Mexican-Americans and non-Hispanic Caucasians. A case-control association study was performed comparing Mexican-Americans with and without coronary artery disease.

RESULTS:

The two ethnic groups exhibited significant genetic differences. Among Mexican-Americans, homozygosity for LPL haplotype 1 was protective against coronary artery disease (OR = 0.50, 95% CI 0.27-0.91).

CONCLUSION:

This study outlines the haplotype structure of the LPL gene, illustrates the utility of haplotype-based analysis in association studies, and demonstrates the importance of defining haplotype frequencies for different ethnic groups.

• Authors: Mark O Goodarzi, Xiuqing Guo, Kent D Taylor, Manuel J Quiñones, Carlos Samayoa, Huiying Yang, Mohammad F Saad, Aarno Palotie, Ronald M Krauss, Willa A Hsueh, Jerome I Rotter
• Journal: Genetics in medicine : official journal of the American College of Medical Genetics (Genet Med) 2003 Jul-Aug Vol. 5 Issue 4 Pg. 322-7 ISSN: 1098-3600 [Print] United States
• PMID: 12865761 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Lipoprotein Lipase

Topics

• Alleles
• Coronary Artery Disease (ethnology, genetics)
• Gene Frequency
• Genotype
• Haplotypes
• Hispanic or Latino
• Homozygote
• Humans
• Lipoprotein Lipase (genetics)
• Logistic Models
• Mexican Americans
• Polymorphism, Genetic
• White People