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Successful use of oral linezolid as a single active agent in endocarditis unresponsive to conventional antibiotic therapy.

Abstract
Treatment of resistant gram-positive endocarditis is difficult. We report a case of resistant Staphylococcus epidermidis endocarditis that failed to respond to conventional antibiotic therapy but was treated successfully with an oral regimen of a new antibiotic, linezolid as a single active agent. This case report demonstrates the use of linezolid as an effective alternative to conventional antibiotics in such cases.
AuthorsV Ravindran, J John, G C Kaye, R E Meigh
JournalThe Journal of infection (J Infect) Vol. 47 Issue 2 Pg. 164-6 (Aug 2003) ISSN: 0163-4453 [Print] England
PMID12860152 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Acetamides
  • Anti-Bacterial Agents
  • Oxazolidinones
  • Linezolid
Topics
  • Acetamides (therapeutic use)
  • Administration, Oral
  • Aged
  • Anti-Bacterial Agents (therapeutic use)
  • Endocarditis, Bacterial (drug therapy, microbiology)
  • Fatal Outcome
  • Female
  • Humans
  • Linezolid
  • Oxazolidinones (therapeutic use)
  • Staphylococcal Infections (drug therapy)
  • Staphylococcus epidermidis (isolation & purification)
  • Treatment Outcome

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