Abstract |
We investigated the effects of two new low molecular weight nonpeptidyl superoxide dismutase (SOD) mimetics ( M40403/ M40401; MetaPhore Pharmaceuticals) on infarct volume after hypoxia- ischemia injury (H/I) in immature rats. Animals received vehicle or different doses of M40403 or M40401 i.p. 2 h before exposure to 3 h of 8% hypoxia. The infarct volume of the hemisphere ipsilateral to carotid ligation 24 h later was 73.9+/-8.9% in vehicle animals (n=9), and decreased to 39.7+/-7.2% (P<0.05, n=10) in animals treated with 3 mg/kg M40403 and to 37.2+/-6.4% for animals receiving 3 mg/kg M40401 (P<0.05, n=8). These data indicate that the SOD mimetics M40403 and M40401 have protective effects against hypoxic-ischemic brain injury, and suggest the involvement of superoxide anion in neuronal cell injury during H/I.
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Authors | Katsuyoshi Shimizu, Nishadi Rajapakse, Takashi Horiguchi, R Mark Payne, David W Busija |
Journal | Neuroscience letters
(Neurosci Lett)
Vol. 346
Issue 1-2
Pg. 41-4
(Jul 31 2003)
ISSN: 0304-3940 [Print] Ireland |
PMID | 12850543
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- M40401
- Neuroprotective Agents
- Organometallic Compounds
- imisopasem manganese
- Manganese
- Superoxide Dismutase
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Topics |
- Animals
- Animals, Newborn
- Brain
(drug effects, enzymology, pathology)
- Hypoxia-Ischemia, Brain
(drug therapy, enzymology, pathology)
- Manganese
- Neuroprotective Agents
(pharmacology, therapeutic use)
- Organometallic Compounds
(pharmacology, therapeutic use)
- Rats
- Rats, Sprague-Dawley
- Superoxide Dismutase
(pharmacology, therapeutic use)
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