[Dapsone-induced sensory peripheral neuropathy].

Abstract

INTRODUCTION:

Peripheral neuropathy is a rare complication of dapsone therapy.

CASE-REPORT:

A 74 year-old woman was treated with dapsone, 50 mg per day, for a linear IgA dermatosis. One month later, the disease was controlled but the patient complained of a sensory peripheral neuropathy, which was documented on electromyographic studies. Dapsone was stopped and symptoms resolved within 24 hours. Three months after the beginning of linear IgA dermatosis, a colic adenocarcinoma was revealed by an acute occlusive syndrome. After surgical resection of the tumor, remission of linear IgA dermatosis was obtained with salazopyrine.

DISCUSSION:

This is a rare side effect of dapsone therapy. Twenty-one cases have been previously reported. In most cases, there was a pure motor or mixed neuropathy. Dapsone therapy was then stopped or decreased. Recovery usually occurs within one year after dapsone therapy is discontinued.

• Authors: L Méry, H Dega, C Prost, L Dubertret
• Journal: Annales de dermatologie et de venereologie (Ann Dermatol Venereol) Vol. 130 Issue 4 Pg. 447-9 (Apr 2003) ISSN: 0151-9638 [Print] France
• Vernacular Title: Polynévrite sensitive induite par la dapsone (Disulone).
• PMID: 12843858 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Anti-Inflammatory Agents, Non-Steroidal
• Immunoglobulin A
• Dapsone

Topics

• Aged
• Anti-Inflammatory Agents, Non-Steroidal (adverse effects, therapeutic use)
• Colorectal Neoplasms (diagnosis)
• Dapsone (adverse effects, therapeutic use)
• Diagnosis, Differential
• Drug Hypersensitivity (diagnosis)
• Electromyography (drug effects)
• Female
• Humans
• Immunoglobulin A (blood)
• Neuritis (chemically induced, diagnosis)
• Paraneoplastic Syndromes (diagnosis, drug therapy)
• Skin Diseases (diagnosis, drug therapy)