Abstract | OBJECTIVE: STUDY DESIGN: RESULTS:
Central precocious puberty occurred before irradiation in four cases and after irradiation in 18. Eleven of the 17 patients with neurofibromatosis 1 had PP. Before irradiation, five of 21 patients lacked GH, zero of 21 lacked thyroid-stimulating hormone, and zero of 13 lacked adrenocorticotropin. After irradiation, 35 of 35 lacked GH, 28 of 35 lacked thyroid-stimulating hormone, and six of 35 lacked adrenocorticotropin; puberty was delayed in 15 patients. Adult height was -0.8 +/- 0.2 SD, below target height (0.2 +/- 0.2 SD, P <.0001), similar in patients with and without PP, but lower in those with neurofibromatosis 1 (-1.4 +/- 0.4 SD) than in those without (-0.3 +/- 0.3 SD, P =.04). CONCLUSIONS:
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Authors | Marion Huguenin, Christine Trivin, Michel Zerah, François Doz, Laurence Brugieres, Raja Brauner |
Journal | The Journal of pediatrics
(J Pediatr)
Vol. 142
Issue 6
Pg. 699-703
(Jun 2003)
ISSN: 0022-3476 [Print] United States |
PMID | 12838200
(Publication Type: Journal Article)
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Topics |
- Body Height
(physiology, radiation effects)
- Child
- Cranial Irradiation
(adverse effects)
- Female
- Growth Disorders
(physiopathology)
- Humans
- Male
- Neurofibromatosis 1
(complications, physiopathology)
- Optic Nerve Neoplasms
(physiopathology, radiotherapy)
- Pituitary Irradiation
(adverse effects)
- Puberty, Precocious
(complications, physiopathology)
- Radiotherapy Dosage
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