[Preliminary clinical evaluation of systemic chemotherapy of invasive cancer of the bladder by the CMV protocol].

Abstract

The authors discuss the results of preliminary clinical trials with chemotherapy with CMV (cisplatin, methotrexate, vinblastine) in the group of 17 patients with the infiltrating cancer of the bladder. Chemotherapy was used as an element of the radical treatment (in 7 patients, i.e. 41.2%) or as ++palliative treatment (in 10 patients, i.e. 58.8%). Objective response to the treatment was noted in 73.3% of the treated patients, including 13.3% of the complete recovery, and 60.0% of partial improvement. In the remaining 26.7% of patients (including all patients with distant metastases) no response to therapy was achieved. Complications of therapy are discussed. Systemic chemotherapy with CMV regimen proved efficient in the infiltrating cancer of the bladder.

• Authors: J Szymanowski, E Koźmińska, A Malewski, A Stokłosa
• Journal: Polski tygodnik lekarski (Warsaw, Poland : 1960) (Pol Tyg Lek) 1992 Jun 15-29 Vol. 47 Issue 24-26 Pg. 525-7 ISSN: 0032-3756 [Print] Poland
• Vernacular Title: Wstepna kliniczna ocena chemioterapii układowej, wg schematu CMV, w naciekajacym raku pecherza moczowego.
• PMID: 1282711 (Publication Type: Clinical Trial, English Abstract, Journal Article)

Chemical References

• Vinblastine
• Cisplatin
• Methotrexate

Topics

• Aged
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Chemotherapy, Adjuvant
• Cisplatin (administration & dosage)
• Cystectomy
• Female
• Humans
• Male
• Methotrexate (administration & dosage)
• Middle Aged
• Neoplasm Invasiveness
• Neoplasm Staging
• Palliative Care
• Preoperative Care
• Remission Induction
• Urinary Bladder Neoplasms (drug therapy, pathology, surgery)
• Vinblastine (administration & dosage)