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Type I lamellar ichthyosis improved by tazarotene 0.1% gel.

Abstract
The efficacy of tazarotene 0.1% gel in a 30-year-old woman with type I lamellar ichthyosis is reported. The drug was applied to 15% of the total body surface area as follows: once daily for 2 weeks, three times a week for further 2 weeks, followed by a once weekly maintenance application. During the first week of treatment there was partial improvement obtained and in the next 14 days further reduction of scaling within the tazarotene-treated areas was observed. After 4 months of maintenance application, there was a marked overall improvement in the treated areas. Side-effects consisted only of mild pruritus, slight burning and irritation. In essence, the therapeutic benefit obtained was comparable with that of systemic retinoids but without the adverse systemic side-effects. As noted in other reports, tazarotene 0.1% gel seems to be a valuable and safe therapeutic option for this severe genodermatosis.
AuthorsG C Marulli, E Campione, M S Chimenti, A Terrinoni, G Melino, L Bianchi
JournalClinical and experimental dermatology (Clin Exp Dermatol) Vol. 28 Issue 4 Pg. 391-3 (Jul 2003) ISSN: 0307-6938 [Print] England
PMID12823301 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Dermatologic Agents
  • Gels
  • Nicotinic Acids
  • tazarotene
Topics
  • Administration, Topical
  • Adult
  • Dermatologic Agents (administration & dosage)
  • Female
  • Gels
  • Humans
  • Ichthyosis (diagnosis, drug therapy, genetics)
  • Nicotinic Acids (administration & dosage)
  • Treatment Outcome

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