Abstract |
The efficacy of tazarotene 0.1% gel in a 30-year-old woman with type I lamellar ichthyosis is reported. The drug was applied to 15% of the total body surface area as follows: once daily for 2 weeks, three times a week for further 2 weeks, followed by a once weekly maintenance application. During the first week of treatment there was partial improvement obtained and in the next 14 days further reduction of scaling within the tazarotene-treated areas was observed. After 4 months of maintenance application, there was a marked overall improvement in the treated areas. Side-effects consisted only of mild pruritus, slight burning and irritation. In essence, the therapeutic benefit obtained was comparable with that of systemic retinoids but without the adverse systemic side-effects. As noted in other reports, tazarotene 0.1% gel seems to be a valuable and safe therapeutic option for this severe genodermatosis.
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Authors | G C Marulli, E Campione, M S Chimenti, A Terrinoni, G Melino, L Bianchi |
Journal | Clinical and experimental dermatology
(Clin Exp Dermatol)
Vol. 28
Issue 4
Pg. 391-3
(Jul 2003)
ISSN: 0307-6938 [Print] England |
PMID | 12823301
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Dermatologic Agents
- Gels
- Nicotinic Acids
- tazarotene
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Topics |
- Administration, Topical
- Adult
- Dermatologic Agents
(administration & dosage)
- Female
- Gels
- Humans
- Ichthyosis
(diagnosis, drug therapy, genetics)
- Nicotinic Acids
(administration & dosage)
- Treatment Outcome
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