Abstract |
In continuation of our previous research, several new thiazolyl/thiazolinyl/benzothiazolyl Schiff bases have been designed, synthesized and identified. The referred compounds are reported to act as lipoxygenase inhibitors affecting inflammation and/or psoriasis. The compounds were screened for their reducing activity (with the stable free radical 1,1- diphenyl-2-picryl-hydrazyl, DPPH) and for inhibition of soybean lipoxygenase (LOX). Anti-inflammatory activity was examined in vivo using the carrageenin induced mice paw edema (32.6-75%). The results are discussed in terms of structural and physicochemical characteristics of the compounds. Compound 2d possessed the highest inhibition 75%.
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Authors | Athina Geronikaki, Dimitra Hadjipavlou-Litina, Maria Amourgianou |
Journal | Farmaco (Societa chimica italiana : 1989)
(Farmaco)
Vol. 58
Issue 7
Pg. 489-95
(Jul 2003)
ISSN: 0014-827X [Print] France |
PMID | 12818687
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anti-Inflammatory Agents
- Antioxidants
- Biphenyl Compounds
- Hydrazines
- Lipoxygenase Inhibitors
- Picrates
- Schiff Bases
- 1,1-diphenyl-2-picrylhydrazyl
- Lipoxygenase
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Topics |
- Animals
- Anti-Inflammatory Agents
(therapeutic use)
- Antioxidants
(chemistry)
- Biphenyl Compounds
- Edema
(chemically induced, drug therapy)
- Hydrazines
- Lipoxygenase
- Lipoxygenase Inhibitors
(therapeutic use)
- Mice
- Mice, Inbred A
- Mice, Inbred AKR
- Picrates
- Schiff Bases
(chemistry, therapeutic use)
- Structure-Activity Relationship
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