Novel thiazolyl, thiazolinyl and benzothiazolyl Schiff bases as possible lipoxygenase's inhibitors and anti-inflammatory agents.

Abstract

In continuation of our previous research, several new thiazolyl/thiazolinyl/benzothiazolyl Schiff bases have been designed, synthesized and identified. The referred compounds are reported to act as lipoxygenase inhibitors affecting inflammation and/or psoriasis. The compounds were screened for their reducing activity (with the stable free radical 1,1-diphenyl-2-picryl-hydrazyl, DPPH) and for inhibition of soybean lipoxygenase (LOX). Anti-inflammatory activity was examined in vivo using the carrageenin induced mice paw edema (32.6-75%). The results are discussed in terms of structural and physicochemical characteristics of the compounds. Compound 2d possessed the highest inhibition 75%.

• Authors: Athina Geronikaki, Dimitra Hadjipavlou-Litina, Maria Amourgianou
• Journal: Farmaco (Societa chimica italiana : 1989) (Farmaco) Vol. 58 Issue 7 Pg. 489-95 (Jul 2003) ISSN: 0014-827X [Print] France
• PMID: 12818687 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Inflammatory Agents
• Antioxidants
• Biphenyl Compounds
• Hydrazines
• Lipoxygenase Inhibitors
• Picrates
• Schiff Bases
• 1,1-diphenyl-2-picrylhydrazyl
• Lipoxygenase

Topics

• Animals
• Anti-Inflammatory Agents (therapeutic use)
• Antioxidants (chemistry)
• Biphenyl Compounds
• Edema (chemically induced, drug therapy)
• Hydrazines
• Lipoxygenase
• Lipoxygenase Inhibitors (therapeutic use)
• Mice
• Mice, Inbred A
• Mice, Inbred AKR
• Picrates
• Schiff Bases (chemistry, therapeutic use)
• Structure-Activity Relationship