A family with a variant form of primary hypertrophic osteoarthropathy restricted to the lower extremities.

Abstract

We report a case of a family with a variant form of primary hypertrophic osteoarthropathy (HOA) restricted to the lower extremities without digital clubbing or cutaneous changes. Three family members suffered from pain, swelling and hyperhidrosis of both feet. X-rays showed destruction and osteoproliferative changes of the metatarsal bones with periostal hyperostosis close to the talus. There was an increased 99m-Tc-MDP uptake in the early phase of bone scintigraphy. Fibrosis of the marrow with stimulated osteoclastic resorption and the presence of detritus synovialitis were visible in a bone and joint biopsy. All known infectious, neurologic, metabolic and malignant diseases, which affect the bone and joints, were excluded.

• Authors: Ruth Seggewiss, Thomas Hess, Christoph Fiehn
• Journal: Joint bone spine (Joint Bone Spine) Vol. 70 Issue 3 Pg. 230-3 (Jun 2003) ISSN: 1297-319X [Print] France
• PMID: 12814767 (Publication Type: Case Reports, Journal Article)

Topics

• Adult
• Female
• Genetic Predisposition to Disease
• Humans
• Hyperhidrosis (complications, pathology)
• Male
• Metatarsal Bones (diagnostic imaging)
• Osteoarthropathy, Primary Hypertrophic (complications, genetics, pathology)
• Pedigree
• Radiography
• Tibia (diagnostic imaging)