[Expression of chemokine in the labial glands of patients with Sjogren's syndrome].

Abstract

OBJECTIVE:

To investigate the expression of chemokine RANTES (regulated upon activation, normal T cell expressed and secreted) and macrophage inflammatory protein 1alpha (MIP-1alpha) in the labial glands of patients with Sjogren's syndrome (SS) and discuss their involvement in SS etiopathology.

METHODS:

Immunohistochemistry was used to examine the expression of RANTES and MIP-1alpha in the specimens of labial gland of 14 cases of primary SS, 7 cases of secondary SS (sSS), and 8 cases of controls, including maxillofacial injury and lip cyst.

RESULTS:

The expression rate of RANTES was 86% (12/14) in the pSS group and 71% (10/14) in the sSS group, and was 0 in the control group (P < 0.01). The expression rate of MIP-1alpha was 86% (5/7) in the pSS group, 71% (5/7) in the sSS group, and 25% (2/8) in the control group (P > 0.05). The RANTES and MIP-1alpha were expressed in the cytoplasm of ductal epithelium and part of infiltrated lymphocytes. The positive expression of RANTES was more evident than that of MIP-1alpha.

CONCLUSION:

RANTES and MIP-1alpha may attract the circulating lymphocytes towards inflammation site of labial gland so as play a crucial role in the pathogenesis of SS etiopathology.

• Authors: Fang Wang, Zhen-gang Wang, Fu-lin Tang
• Journal: Zhonghua yi xue za zhi (Zhonghua Yi Xue Za Zhi) Vol. 83 Issue 3 Pg. 220-3 (Feb 10 2003) ISSN: 0376-2491 [Print] China
• PMID: 12812666 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Chemokine CCL3
• Chemokine CCL4
• Chemokine CCL5
• Macrophage Inflammatory Proteins

Topics

• Adult
• Chemokine CCL3
• Chemokine CCL4
• Chemokine CCL5 (analysis, biosynthesis)
• Endothelium (chemistry)
• Female
• Humans
• Immunohistochemistry
• Lip
• Macrophage Inflammatory Proteins (analysis, biosynthesis)
• Male
• Middle Aged
• Salivary Glands, Minor (metabolism)
• Sjogren's Syndrome (metabolism)