Is the Ecstasy-induced ipsilateral rotation in 6-hydroxydopamine unilaterally lesioned rats dopamine independent?

Abstract

3,4-Methylenedioxymethamphetamine (MDMA) has recently been hypothesized to be effective against the symptoms of Parkinson's disease. Therefore we tested the effects of MDMA-derivatives in the rotational behavioural model. Male Sprague Dawley rats were lesioned unilaterally with 6-hydroxydopamine at the medial forebrain bundle. MDMA was administered at doses of 2.5, 5.0 and 10.0 mg/kg, its derivatives N-Methyl-1-(1,3-benzodioxol-5-yl)-2-butananamine (MBDB), 3,4-Methylenedioxy-N-ethylamphetamine (MDE) and 3,4-Methylenedioxyamphetamine (MDA) at 5.0 mg/kg respectively. All substances induced ipsilateral rotations, MDA being the most effective. MDMA induced rotations were attenuated by the selective serotonin reuptake inhibitor Citalopram but were only slightly reduced by pre-treatment with the selective serotonin synthesis inhibitor PCPA (para-chlorophenylalanine). The effects of MDMA can therefore not fully be explained by serotonin release or by dopaminergic activity of the drugs.

• Authors: H B Lebsanft, A Mayerhofer, K-A Kovar, W J Schmidt
• Journal: Journal of neural transmission (Vienna, Austria : 1996) (J Neural Transm (Vienna)) Vol. 110 Issue 7 Pg. 707-18 (Jul 2003) ISSN: 0300-9564 [Print] Austria
• PMID: 12811632 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Adrenergic Agents
• Hallucinogens
• Serotonin Antagonists
• Serotonin Uptake Inhibitors
• Citalopram
• N-methyl-1-(1,3-benzodioxol-5-yl)-2-butanamine
• 3,4-Methylenedioxyamphetamine
• Oxidopamine
• N-Methyl-3,4-methylenedioxyamphetamine
• 3,4-methylenedioxyethamphetamine
• Apomorphine
• Fenclonine
• Dopamine

Topics

• 3,4-Methylenedioxyamphetamine (analogs & derivatives, pharmacology)
• Adrenergic Agents (pharmacology)
• Animals
• Apomorphine (pharmacology)
• Behavior, Animal (drug effects)
• Citalopram (pharmacology)
• Dopamine (metabolism)
• Fenclonine (pharmacology)
• Functional Laterality
• Hallucinogens (pharmacology)
• Male
• Medial Forebrain Bundle (drug effects, physiopathology)
• Models, Animal
• N-Methyl-3,4-methylenedioxyamphetamine (pharmacology)
• Oxidopamine (pharmacology)
• Parkinson Disease (physiopathology)
• Rats
• Rats, Sprague-Dawley
• Rotation
• Serotonin Antagonists (pharmacology)
• Selective Serotonin Reuptake Inhibitors (pharmacology)