Abstract | OBJECTIVES: The purpose of this study was to test the hypothesis that the longer duration of ventricular action potentials in hypertrophied hearts predisposes to the development of early after-depolarizations and triggered ventricular tachyarrhythmias. BACKGROUND: METHODS: RESULTS: CONCLUSIONS: Although in vitro studies have shown that fibers of hypertrophied ventricular myocardium can develop triggered activity as a result of both early and late afterdepolarizations, the present study is the first to show in vivo that the hypertrophied ventricular myocardium compared with the normal ventricle is predisposed to develop phase 2 early afterdepolarizations that appear to trigger ventricular tachyarrhythmia. It is possible that such a mechanism contributes to the development of ventricular tachyarrhythmia and sudden cardiac death in patients with left ventricular hypertrophy. If this is shown to be true, specific pharmacologic interventions can be suggested.
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Authors | J Ben-David, D P Zipes, G M Ayers, H P Pride |
Journal | Journal of the American College of Cardiology
(J Am Coll Cardiol)
Vol. 20
Issue 7
Pg. 1576-84
(Dec 1992)
ISSN: 0735-1097 [Print] United States |
PMID | 1280660
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Cesium
- Phenylephrine
- 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester
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Topics |
- 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester
(administration & dosage, adverse effects)
- Action Potentials
(drug effects)
- Animals
- Causality
- Cesium
(adverse effects)
- Death, Sudden, Cardiac
(epidemiology, etiology)
- Disease Models, Animal
- Dogs
- Evaluation Studies as Topic
- Hemodynamics
(drug effects)
- Hypertrophy, Left Ventricular
(complications, drug therapy, pathology)
- Incidence
- Organ Size
(drug effects)
- Phenylephrine
(adverse effects)
- Prevalence
- Tachycardia, Ventricular
(chemically induced, diagnosis, epidemiology)
- Time Factors
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