Lymphomatoid granulomatosis in a renal transplant patient.

Abstract

Lymphomatoid granulomatosis is a rare angiocentric and angiodestructive pulmonary angiitis considered as a variant of the lymphoproliferative disorder group. Patients with organ transplantation are at an increased risk for post-transplant lymphoproliferative disorders secondary to their immunosuppression. However, lymphomatoid granulomatosis has rarely been described in patients with renal transplantation. It often presents with severe pulmonary signs. We describe a case whose initial presentation was an isolated VIth nerve palsy. We review the radiological and pathological findings and discuss the etiopathogenesis and therapeutic options of this particular lymphoproliferative disorder. With careful and stepwise reduction in her immunosuppression, our patient showed a complete disappearance of her lymphomatoid granulomatosis, and she is clinically well more than 3 years after the diagnosis, with good kidney function.

• Authors: François Cachat, Kathleen Meagher-Villemure, Jean-Pierre Guignard
• Journal: Pediatric nephrology (Berlin, Germany) (Pediatr Nephrol) Vol. 18 Issue 8 Pg. 838-42 (Aug 2003) ISSN: 0931-041X [Print] Germany
• PMID: 12802639 (Publication Type: Case Reports, Journal Article)

Chemical References

• Immunosuppressive Agents

Topics

• Adolescent
• Female
• Graft Rejection (drug therapy)
• Humans
• Immunosuppressive Agents (adverse effects)
• Kidney Transplantation
• Lymphomatoid Granulomatosis (chemically induced, pathology)
• Magnetic Resonance Imaging
• Tomography, X-Ray Computed