Abstract | BACKGROUND: AIMS: PATIENTS AND METHODS: A total of 96 patients with acute peptic ulcer bleeding without proton pump inhibitor or antibiotic therapy within the last 14 days before bleeding were included into the study. During index endoscopy, specimens for histological and rapid urease test were obtained from the antrum and corpus mucosa of the stomach. Patients were also investigated by the 13C-urea breath test. Diagnostic quality parameters were calculated with the histology and the 13C-urea breath test as reference and compared with a matched control group with uncomplicated ulcers. RESULTS: The sensitivity of the rapid urease test was 80% and the specificity 100% compared to histology and 13C-urea breath test. The negative predictive value was 75%. These values were statistically significantly different from those of the control group (sensitivity 96%, specificity 100%, negative predictive value 88%). CONCLUSION:
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Authors | D Schilling, A Demel, H E Adamek, T Nüsse, E Weidmann, J F Riemann |
Journal | Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
(Dig Liver Dis)
Vol. 35
Issue 4
Pg. 217-21
(Apr 2003)
ISSN: 1590-8658 [Print] Netherlands |
PMID | 12801031
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Breath Tests
- Case-Control Studies
- Duodenal Ulcer
(complications, microbiology)
- Endoscopy, Digestive System
- False Negative Reactions
- Female
- Gastric Mucosa
(microbiology, pathology)
- Helicobacter Infections
(diagnosis)
- Helicobacter pylori
(isolation & purification)
- Humans
- Male
- Middle Aged
- Peptic Ulcer Hemorrhage
(microbiology)
- Predictive Value of Tests
- Prevalence
- Prospective Studies
- Pyloric Antrum
(microbiology, pathology)
- Reference Values
- Reproducibility of Results
- Sensitivity and Specificity
- Urea
- Urease
(analysis)
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