Abstract | PURPOSE: The risk for death in patients with retinoblastoma is increased in those who present with metastatic disease, and the role of intensive chemotherapy and autologous hematopoietic stem cell rescue in these patients remains unclear. DESIGN: Nonrandomized interventional case series. PARTICIPANTS: METHODS: MAIN OUTCOME MEASURES: Patient survival. RESULTS: All patients completed and responded to the scheduled therapy; complete response of the bone marrow disease was documented after two courses of chemotherapy in all cases. Two patients are long-term survivors. CONCLUSIONS: The treatment described has been successful in obtaining disease-free survival in patients with metastatic retinoblastoma.
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Authors | Carlos Rodriguez-Galindo, Matthew W Wilson, Barrett G Haik, Mindy J Lipson, Alvida Cain, Thomas E Merchant, Sue Kaste, Charles B Pratt |
Journal | Ophthalmology
(Ophthalmology)
Vol. 110
Issue 6
Pg. 1237-40
(Jun 2003)
ISSN: 0161-6420 [Print] United States |
PMID | 12799253
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
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Topics |
- Antineoplastic Combined Chemotherapy Protocols
(therapeutic use)
- Bone Marrow Neoplasms
(mortality, secondary, therapy)
- Bone Neoplasms
(mortality, secondary, therapy)
- Child, Preschool
- Disease-Free Survival
- Eye Enucleation
- Eye Neoplasms
(mortality, pathology, therapy)
- Female
- Hematopoietic Stem Cell Transplantation
- Humans
- Infant
- Male
- Radiotherapy, Adjuvant
- Retinoblastoma
(mortality, secondary, therapy)
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