[A case of gastric cancer with metastasis to cervical lymph nodes and pulmonary lymphangitis carcinomatosa responding to neoadjuvant chemotherapy with TS-1 and CDDP].

Abstract

The patient was a 61-year-old man who had gastric cancer with metastasis to cervical lymph nodes and pulmonary lymphangitis carcinomatosa. He received daily oral administration of 120 mg of TS-1 (day 1-21) and systemic administration of 100 mg of CDDP (day 8) as one treatment course. As the metastatic lesions had disappeared after chemotherapy, he underwent total gastrectomy. Histopathological examination of resected regional lymph nodes revealed marked fibrosis and a small amount of scattered cancer cells. Although much peritoneal dissemination was observed macroscopically, histopathological examination of these tumors revealed only fibrosis with no cancer cells. These findings supported the effect of this neoadjuvant chemotherapy. He died of recurrence of the carcinoma 203 days after surgery, without any sign of recurrence of metastasis to cervical lymph nodes or pulmonary lymphangitis carcinomatosa.

• Authors: Ken-ichi Takahashi, Kikuo Miyagawa, Yasushi Mitachi, Takayuki Masuda, Takahiko Oogoshi
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 30 Issue 5 Pg. 685-9 (May 2003) ISSN: 0385-0684 [Print] Japan
• PMID: 12795102 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Drug Combinations
• Pyridines
• S 1 (combination)
• Tegafur
• Oxonic Acid
• Cisplatin

Topics

• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Carcinoma (drug therapy, secondary, surgery)
• Cisplatin (administration & dosage)
• Drug Combinations
• Gastrectomy
• Humans
• Lung Neoplasms (secondary)
• Lymphangitis (complications)
• Lymphatic Metastasis
• Male
• Middle Aged
• Oxonic Acid (administration & dosage)
• Pyridines (administration & dosage)
• Stomach Neoplasms (drug therapy, pathology, surgery)
• Tegafur (administration & dosage)