The cholecystokinin antagonist proglumide enhances the analgesic effect of dihydrocodeine.

Abstract

AIM:

To investigate the potential pro-analgesic effect of the non-specific CCK antagonist proglumide on the analgesia produced by dihydrocodeine.

METHOD:

A double-blind, placebo-controlled crossover study of 30 adult subjects.

RESULTS:

Mean pain scores fell from a baseline of 8.12-7.89 during the placebo phase (N.S.) and to 6.82 during the proglumide phase (P < 0.05). Side effects were minor.

CONCLUSION:

The CCK antagonist proglumide enhances the analgesic effect of dihydrocodeine.

• Authors: Gary J McCleane
• Journal: The Clinical journal of pain (Clin J Pain) 2003 May-Jun Vol. 19 Issue 3 Pg. 200-1 ISSN: 0749-8047 [Print] United States
• PMID: 12792559 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)

Chemical References

• Analgesics
• Cholecystokinin
• Proglumide
• dihydrocodeine
• Codeine

Topics

• Adult
• Aged
• Analgesics (administration & dosage)
• Cholecystokinin (antagonists & inhibitors)
• Chronic Disease
• Codeine (administration & dosage, analogs & derivatives)
• Cross-Over Studies
• Double-Blind Method
• Drug Synergism
• Drug Therapy, Combination
• Female
• Humans
• Male
• Middle Aged
• Pain (drug therapy)
• Placebo Effect
• Proglumide (administration & dosage)
• Treatment Outcome