Abstract | BACKGROUND: OBJECTIVE: DESIGN: A standardized, commercially available, sandwich fluoroimmunometric serum thyroglobulin assay was adapted for use on blood spots and validated in Swiss children. In a 1-y prospective study in 377 goitrous Moroccan children aged 6-15 y, the assay was used to measure thyroglobulin before and after the introduction of iodized salt. Urinary iodine, thyroid volume, thyrotropin, and thyroxine were measured, and regression was done with thyroglobulin as the dependent variable. RESULTS: Correlation between the blood spot and serum assays was excellent (r = 0.98). The SD of the difference between the blood spot and serum assays was 3.8 micro g/L; the median CVs for the blood spot assay in controls and samples were 6.3% and 14.4%, respectively. Median thyroglobulin was 24.5 (range: 0-328.8) micro g/L at baseline and fell significantly after the introduction of iodized salt to 6.2 (0-83.1) and 4.4 (0-47.1) micro g/L at 5 and 12 mo, respectively (P < 0.0001). Regression of urinary iodine and thyroid volume on thyroglobulin was highly significant at baseline and at 5 mo (P < 0.001). CONCLUSION:
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Authors | Michael B Zimmermann, Diego Moretti, Noureddine Chaouki, Toni Torresani |
Journal | The American journal of clinical nutrition
(Am J Clin Nutr)
Vol. 77
Issue 6
Pg. 1453-8
(Jun 2003)
ISSN: 0002-9165 [Print] United States |
PMID | 12791623
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Validation Study)
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Chemical References |
- Sodium Chloride, Dietary
- iodized salt
- Thyroglobulin
- Iodine
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Topics |
- Adolescent
- Child
- Female
- Goiter, Endemic
(blood, drug therapy, physiopathology)
- Hematologic Tests
(methods)
- Humans
- Iodine
(administration & dosage)
- Male
- Morocco
- Schools
- Sodium Chloride, Dietary
(administration & dosage, therapeutic use)
- Thyroglobulin
(analysis)
- Thyroid Function Tests
- Thyroid Gland
(physiopathology)
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