Microbiology of mandibular third molar pericoronitis: incidence of beta-lactamase-producing bacteria.

Abstract

OBJECTIVES:

The purpose of this study was to evaluate the predominant flora associated with pericoronitis in third molars and to investigate the presence of beta-lactamase-producing strains.

STUDY DESIGN:

The third molars in 26 adults were evaluated by cultures with nonselective media and with selective media containing amoxicillin, pristinamycin, spiramycin, metronidazole, and spiramycin plus metronidazole.

RESULTS:

In the majority of cases (19/26), the flora found in an anaerobic atmosphere predominated. Obligate anaerobes were present in 21 of the 26 samples. The bacteria most commonly detected were alpha-hemolytic streptococci (26/26) and the genera Prevotella (15/26), Veillonella (15/26), Bacteroides (9/26), and Capnocytophaga (9/26). Amoxicillin and pristinamycin were the most active in reducing the anaerobic cultivable counts. beta-Lactamase-producing strains were detected in 9 samples and were mostly bacteria of the genera Prevotella, Staphylococcus, and Bacteroides.

CONCLUSIONS:

These results highlight (1) the diversity of the microflora associated with pericoronitis and the importance of the anaerobic flora and (2) the existence of selection pressure related to the use of beta-lactams that may culminate in failure of prescribed penicillins.

• Authors: Jean-Louis Sixou, Christophe Magaud, Anne Jolivet-Gougeon, Michel Cormier, Martine Bonnaure-Mallet
• Journal: Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics (Oral Surg Oral Med Oral Pathol Oral Radiol Endod) Vol. 95 Issue 6 Pg. 655-9 (Jun 2003) ISSN: 1079-2104 [Print] United States
• PMID: 12789143 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Bacterial Agents
• Penicillins
• Pristinamycin
• Metronidazole
• Spiramycin
• Amoxicillin
• beta-Lactamases

Topics

• Adolescent
• Adult
• Amoxicillin (pharmacology)
• Anti-Bacterial Agents (pharmacology)
• Bacteria, Anaerobic (classification, enzymology)
• Bacteroides (classification, drug effects)
• Female
• Humans
• Male
• Mandible
• Metronidazole (pharmacology)
• Molar, Third (microbiology)
• Penicillins (pharmacology)
• Pericoronitis (microbiology)
• Prevotella (classification, drug effects)
• Pristinamycin (pharmacology)
• Spiramycin (pharmacology)
• Streptococcus (classification, drug effects)
• Veillonella (classification, drug effects)
• beta-Lactam Resistance
• beta-Lactamases (metabolism)