The molecular basis of the antigenic cross-reactivity between measles and cowpea mosaic viruses.

Abstract

Two nonrelated viruses, cowpea mosaic virus (wtCPMV) and measles virus (MV), were found to induce cross-reactive antibodies. The nature of this cross-reactivity was studied and results are presented here demonstrating that antiserum raised against wtCPMV reacted with peptide from the fusion (F) protein of MV. Furthermore, the F protein of MV was shown to share an identical conformational B cell epitope with the small subunit of CPMV coat protein. Passive transfer of anti-wtCPMV antibodies into BALB/c mice conferred partial protection against measles virus induced encephalitis. The results are discussed in the context of cross-protection.

• Authors: Wieslawa Olszewska, Michael W Steward
• Journal: Virology (Virology) Vol. 310 Issue 1 Pg. 183-9 (May 25 2003) ISSN: 0042-6822 [Print] United States
• PMID: 12788642 (Publication Type: Journal Article)

Chemical References

• Antibodies, Viral
• Capsid Proteins
• Immune Sera
• Viral Fusion Proteins

Topics

• Amino Acid Sequence
• Animals
• Antibodies, Viral (immunology)
• Capsid Proteins (chemistry, immunology)
• Comovirus (immunology)
• Cross Reactions
• Encephalitis, Viral (prevention & control)
• Female
• Immune Sera (immunology)
• Immunization, Passive
• Measles virus (immunology)
• Mice
• Mice, Inbred BALB C
• Molecular Sequence Data
• Rabbits
• Sequence Homology
• Viral Fusion Proteins (chemistry, immunology)