Abstract | BACKGROUND: METHODS: The expression of moesin was evaluated immunohistochemically in paraffin-embedded tissues of 59 specimens of OSCC, 35 specimens of OED, 17 specimens of VC, and five specimens of normal oral epithelium. RESULTS: In the normal oral epithelia, all specimens showed a pattern of membranous expression against the anti- moesin antibody in the basal layer cells. In the OED specimens, moesin was dominantly expressed in the cell membrane except for the cornified layer. In VC and OSCC specimens, almost the whole of the carcinoma cells were stained with anti- moesin antibody. However, in OSCC samples, moesin was markedly expressed increasingly in the cytoplasm and decreasingly in the cell membrane, as compared with OED and VC. In addition, there was a significant correlation between the pattern of moesin expression and tumor differentiation in OSCC. CONCLUSIONS: Our results suggest that it is useful to detect the moesin expression as adjunct to screening mucosal lesions in the oral cavity.
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Authors | Hiroichi Kobayashi, Junji Sagara, Junya Masumoto, Hiroshi Kurita, Kenji Kurashina, Shuníichiro Taniguchi |
Journal | Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
(J Oral Pathol Med)
Vol. 32
Issue 6
Pg. 344-9
(Jul 2003)
ISSN: 0904-2512 [Print] Denmark |
PMID | 12787041
(Publication Type: Journal Article)
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Chemical References |
- Antibodies, Monoclonal
- Microfilament Proteins
- moesin
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Topics |
- Adult
- Antibodies, Monoclonal
- Carcinoma, Squamous Cell
(chemistry, metabolism)
- Carcinoma, Verrucous
(chemistry, metabolism)
- Cell Membrane
(chemistry, metabolism)
- Cytoplasm
(chemistry, metabolism)
- Epithelial Cells
(chemistry)
- Female
- Humans
- Immunohistochemistry
- Male
- Microfilament Proteins
(analysis, biosynthesis)
- Middle Aged
- Mouth Mucosa
(chemistry, metabolism)
- Mouth Neoplasms
(chemistry, metabolism)
- Precancerous Conditions
(chemistry, metabolism)
- Statistics, Nonparametric
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