Photodynamic therapy (PDT) using topically applied delta-aminolevulinic acid (ALA) for the treatment of oral leukoplakia.

Abstract

BACKGROUND:

Photodynamic therapy (PDT) is a non-invasive method for topical and selective treatment of pre-malignant lesions of oral cavity. The aim of our study was to determine therapeutic response to PDT in patients with oral leukoplakia.

METHODS:

Twelve patients participated in our study. Lesions affected a variety of intraoral sites. The most common location was buccal, gingival and mandibular mucosa. Patients were treated with topically applied 10% delta-aminolevulinic acid (ALA) and light from an argon-pumped dye laser. Irradiation was performed in several (6-8) sessions using light at 635 nm wavelength, delivering a total dose of 100 J/cm2 per session.

RESULTS:

A complete response was obtained in 10 out of 12 treated patients. One recurrence was observed during 6 months.

CONCLUSION:

Photodynamic therapy appears to be a feasible alternative to conventional therapy of pre-malignant lesions of oral cavity.

• Authors: Aleksander Sieroń, Mariusz Adamek, Aleksandra Kawczyk-Krupka, Sebastian Mazur, Leszek Ilewicz
• Journal: Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology (J Oral Pathol Med) Vol. 32 Issue 6 Pg. 330-6 (Jul 2003) ISSN: 0904-2512 [Print] Denmark
• PMID: 12787039 (Publication Type: Journal Article)

Chemical References

• Photosensitizing Agents
• Aminolevulinic Acid

Topics

• Administration, Topical
• Adult
• Aged
• Aminolevulinic Acid (administration & dosage, therapeutic use)
• Humans
• Laser Therapy
• Leukoplakia, Oral (drug therapy)
• Middle Aged
• Photochemotherapy
• Photosensitizing Agents (administration & dosage, therapeutic use)