Successful treatment of partial nephrogenic diabetes insipidus with thiazide and desmopressin.

Abstract

OBJECTIVE:

To clarify whether combination treatment with desmopressin (DDAVP) and thiazide was clinically effective in a patient with congenital nephrogenic diabetes insipidus (CNDI), we evaluated the treatment in a 7-year-old boy with CNDI who had demonstrated a partial response to DDAVP.

METHOD:

Both volume of urine and the presence of nocturia were determined during treatment.

RESULT:

Neither the usual therapy of a low-salt diet and a thiazide nor intranasal therapy with a large dose of DDAVP was effective. However, combination treatment resulted in a decrease in urinary volume and the disappearance of nocturia.

CONCLUSION:

DDAVP coupled with thiazide may be useful for CNDI in patients who have shown a partial response to DDAVP.

• Authors: Haruo Mizuno, Shinji Fujimoto, Yukari Sugiyama, Masanori Kobayashi, Yoichiro Ohro, Shinichi Uchida, Sei Sasaki, Hajime Togari
• Journal: Hormone research (Horm Res) Vol. 59 Issue 6 Pg. 297-300 ( 2003) ISSN: 0301-0163 [Print] Switzerland
• PMID: 12784095 (Publication Type: Case Reports, Journal Article)
• Copyright: Copyright 2003 S. Karger AG, Basel

Chemical References

• Diuretics
• Renal Agents
• Sodium Chloride Symporter Inhibitors
• Deamino Arginine Vasopressin
• Trichlormethiazide

Topics

• Deamino Arginine Vasopressin (therapeutic use)
• Diabetes Insipidus, Nephrogenic (complications, drug therapy)
• Diuresis (drug effects)
• Diuretics
• Drug Therapy, Combination
• Humans
• Infant
• Male
• Renal Agents (therapeutic use)
• Sodium Chloride Symporter Inhibitors (therapeutic use)
• Treatment Outcome
• Trichlormethiazide (therapeutic use)
• Urination Disorders (drug therapy, etiology)