HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Development of vaccines to control bovine tuberculosis in cattle and relationship to vaccine development for other intracellular pathogens.

Abstract
Vaccination of cattle against bovine tuberculosis could be an important strategy for the control of disease either where there is a wildlife reservoir of Mycobacterium bovis infection or in developing countries where it is not economically feasible to implement a 'test and slaughter' control program. Advances in the understanding of protective immune responses to M. bovis infection in cattle and the advent of new molecular biological techniques, coupled with the sequencing of the M. bovis genome have provided opportunities for the rational development of improved tuberculosis vaccines. A number of new tuberculosis vaccines including attenuated M. bovis strains, killed mycobacteria, protein and DNA vaccines are under development and many are being assessed in cattle. Recent results have revealed several promising vaccine candidates and vaccination strategies. Ways of distinguishing between vaccinated and infected cattle are becoming available and the possibility of new approaches to the eradication of tuberculosis from domestic livestock is discussed. Similarities between the mechanisms of protective immunity against M. bovis and against other intracellular parasites continue to be found and discoveries from vaccine studies on bovine tuberculosis may provide helpful insights into requirements for vaccines against other intracellular pathogens.
AuthorsBryce M Buddle, John M Pollock, Margot A Skinner, D Neil Wedlock
JournalInternational journal for parasitology (Int J Parasitol) Vol. 33 Issue 5-6 Pg. 555-66 (May 2003) ISSN: 0020-7519 [Print] England
PMID12782055 (Publication Type: Journal Article, Review)
Chemical References
  • BCG Vaccine
  • Bacterial Proteins
  • Tuberculosis Vaccines
  • Vaccines, Attenuated
  • Vaccines, DNA
Topics
  • Animals
  • Animals, Newborn (immunology)
  • Animals, Wild (immunology)
  • BCG Vaccine (immunology, therapeutic use)
  • Bacterial Proteins (immunology)
  • Cattle
  • Developing Countries
  • Genome, Bacterial
  • Immunity, Cellular (immunology)
  • Mycobacterium bovis (genetics, immunology, pathogenicity)
  • Tuberculosis Vaccines (immunology, therapeutic use)
  • Tuberculosis, Bovine (diagnosis, immunology, prevention & control)
  • Vaccination (methods)
  • Vaccines, Attenuated (immunology, therapeutic use)
  • Vaccines, DNA (immunology, therapeutic use)
  • Virulence

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: