Abstract | BACKGROUND: METHODS: Our study included 13 patients with biopsy-proven prostate cancer, stage D3. Eight patients had been treated with a depot formulation of the agonist D-Trp-6-LH-RH, with a median remission time of 68 (range 48-102 months). Five patients were initially treated by surgical orchiectomy, but relapsed after a median time of 33 months (range 17-91 months). A new remission period with a median duration of 10 months (range 2-29 months) was induced with Ketoconazole in the orchiectomy group. At the relapse time, all the patients received 1 mg of vapreotide t.i.d., by subcutaneous route, in addition to D-Trp-6-LH-RH, or Ketoconazole in the orchiectomy group. RESULTS: Eight of 13 patients demonstrated clinical improvement after 3 months of therapy with vapreotide, six showing a decrease in serum prostate specific antigen (PSA) from 234.5 +/- 308.5 to 68.2 +/- 60.5 ng/ml (mean decline 71 +/- 8%; P < 0.05). Two additional patients presented a fall in serum prostatic acid phosphatase (PAP). Responding patients showed a decrease in the bone pain score from 2.62 +/- 0.48 to 0.37 +/- 0.69 and an increase in the Karnofsky performance status from 72.3 +/- 4.21 to 83.6 +/- 23.2 (P < 0.05). In accord with the ECOG criteria, two patients had a complete response; four had partial response, and two had a stable response. Four patients did not respond and one was not evaluable. Two patients died in remission, one at 16 months due to myocardial infarction and the other at 24 months due to pneumonia. Three patients relapsed at 5, 17, and 19 months respectively. Three patients who have been followed-up for more than 3 years continued in remission (79, 45, and 45 months) respectively. Vapreotide was well tolerated, only three patients having transitory mild diarrhea. CONCLUSIONS:
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Authors | David González-Barcena, Andrew V Schally, Manuel Vadillo-Buenfil, Adolfo Cortez-Morales, Victor Hernández L, Imelda Cardenas-Cornejo, Ana Maria Comaru-Schally |
Journal | The Prostate
(Prostate)
Vol. 56
Issue 3
Pg. 183-91
(Aug 01 2003)
ISSN: 0270-4137 [Print] United States |
PMID | 12772187
(Publication Type: Journal Article)
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Copyright | Copyright 2003 Wiley-Liss, Inc. |
Chemical References |
- Antineoplastic Agents
- Delayed-Action Preparations
- vapreotide
- Somatostatin
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Topics |
- Adult
- Aged
- Antineoplastic Agents
(administration & dosage, adverse effects, pharmacology)
- Delayed-Action Preparations
- Health Status
- Humans
- Male
- Middle Aged
- Neoplasm Recurrence, Local
(drug therapy)
- Pain
- Prostatic Neoplasms
(drug therapy, pathology, surgery)
- Somatostatin
(administration & dosage, adverse effects, analogs & derivatives, pharmacology)
- Survival Analysis
- Treatment Outcome
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