Gene expression of type I collagen in neoplastic chondrocytes.

Abstract

In the present examination, we detected type I collagen mRNA in neoplastic chondrocytes in osteochondromas, typical benign bone neoplasms. We believe that the cells involved in >chondroid bone< appearing in osteochondromas temporally express cartilage phenotypes and then change directly into bone-forming cells that survive in the >chondroid bone< until the tissue is resorbed and remodelled into true bone tissue.

• Authors: A Kimura, Toshiyuki Kawakami, S Matsuura, H Hasegawa, H Kanda, H Tujigiwa, H Nagatsuka, N Nagai
• Journal: European journal of medical research (Eur J Med Res) Vol. 8 Issue 4 Pg. 165-7 (Apr 30 2003) ISSN: 0949-2321 [Print] England
• PMID: 12765863 (Publication Type: Journal Article)

Chemical References

• Collagen Type I
• RNA, Messenger
• RNA, Neoplasm

Topics

• Adolescent
• Adult
• Bone Neoplasms (genetics, metabolism, pathology)
• Child
• Child, Preschool
• Chondrocytes (metabolism, pathology)
• Collagen Type I (genetics)
• Female
• Gene Expression
• Humans
• Male
• Osteochondroma (genetics, metabolism, pathology)
• RNA, Messenger (genetics, metabolism)
• RNA, Neoplasm (genetics, metabolism)