A case of malignant syndrome associated with a parkinsonism patient.

Abstract

Malignant syndrome is usually triggered by an excessive use of neuroleptics and dehydration. In the patients with Parkinson's disease, it is sometimes provoked by discontinuation of anti-Parkinsonism agents. Nevertheless, there are few reports describing malignant syndrome in Parkinson's disease patients and no typical therapeutic strategy had been established in such cases. We recently experienced a case of malignant syndrome associated with a familial Parkinsonism patient, which was brought about by surgical invasion and a break in the administration of anti-Parkinsonism agents. Respiratory muscle paralysis, megacolon, and nocturnal delirium observed in this patient might have partially resulted from the use of dantrolene administered during the course of the treatment. Since an increase in the sensitivity to certain drugs is presumed in Parkinson's disease patients, we should be sufficiently cautious about drug administration. We should administer dantrolene, recognizing the fact that the use of dantrolene is one of the symptomatic treatments for muscle rigidity.

• Authors: Masaki Sanga, Soichiro Nomura
• Journal: Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology (Nihon Shinkei Seishin Yakurigaku Zasshi) Vol. 23 Issue 2 Pg. 91-5 (Apr 2003) ISSN: 1340-2544 [Print] Japan
• PMID: 12762221 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antiparkinson Agents
• Muscle Relaxants, Central
• Dantrolene

Topics

• Antiparkinson Agents (adverse effects)
• Dantrolene (therapeutic use)
• Fluid Therapy
• Humans
• Male
• Middle Aged
• Muscle Relaxants, Central (therapeutic use)
• Neuroleptic Malignant Syndrome (etiology, therapy)
• Parkinson Disease (complications, drug therapy)
• Substance Withdrawal Syndrome (etiology, therapy)