[The protein expression of Bcl-x1 and Bcl-2 in eosinophils in nasal polyps and the influence of beclomethasone dipropionate on the expression].

Abstract

OBJECTIVE:

To investigate the protein expression of B-cell lymphoma/leukemia-2(Bcl-2) and B-cell lymphoma/leukemia-x long(Bcl-x1) in eosinophils in nasal polyps and the influence of beclomethasone dipropionate on the expression.

METHODS:

Using May-Grünwald-Giemsa (MGG) method and immunohistochemical method, the protein expression of Bcl-x1 and Bcl-2 in eosinophils in nasal polyps from patients treated with beclomethasone dipropionate treatment and patients without any treatment was compared.

RESULTS:

(1) Nasal polyp tissues from patients without treatment had more eosinophils than those from patients with treatment(P < 0.01). (2) No protein expression of Bcl-2 was observed in all 52 patients. (3) 20.0% patients with treatment had the expression of Bcl-x1, whereas 48.1% patients without treatment had the expression. The difference between these two groups was significant(P < 0.05).

CONCLUSION:

These data suggest that Bcl-x1 may act as an anti-apoptotic molecule in eosinophils and corticosteroids induce eosinophil apoptosis through suppressing the expression of Bcl-x1.

• Authors: Z Liu, Q Gao, J Zhang, X You, Y Cui
• Journal: Zhonghua er bi yan hou ke za zhi (Zhonghua Er Bi Yan Hou Ke Za Zhi) Vol. 36 Issue 2 Pg. 90-3 (Apr 2001) ISSN: 0412-3948 [Print] China
• PMID: 12761970 (Publication Type: English Abstract, Journal Article)

Chemical References

• BCL2L1 protein, human
• Proto-Oncogene Proteins c-bcl-2
• bcl-X Protein
• Beclomethasone

Topics

• Adolescent
• Adult
• Apoptosis (drug effects)
• Beclomethasone (pharmacology)
• Eosinophils (metabolism)
• Female
• Humans
• Male
• Middle Aged
• Nasal Polyps (pathology)
• Proto-Oncogene Proteins c-bcl-2 (biosynthesis)
• bcl-X Protein