Increased procollagen alpha1(I) mRNA expression by dermal fibroblasts in melorheostosis.

Abstract

We report a patient with melorheostosis in whom increased procollagen alpha1(I) mRNA expression and alpha1(I), alpha2(I) and alpha1(III) collagen secretion were observed in dermal fibroblasts obtained from a skin biopsy overlying the involved bone. The patient was a 53-year-old man with melorheostosis lesions over the left knee joint. Multiple pigmented macules were present on the medial aspect of the lower left leg. Hyperpigmentation of the basal keratinocytes, thick-walled vessels in the reticular dermis, and proliferation of normal-appearing collagen around the hair follicles were observed histologically.

• Authors: H Endo, A Katsumi, K Kuroda, A Utani, H Moriya, H Shinkai
• Journal: The British journal of dermatology (Br J Dermatol) Vol. 148 Issue 4 Pg. 799-803 (Apr 2003) ISSN: 0007-0963 [Print] England
• PMID: 12752142 (Publication Type: Case Reports, Journal Article)

Chemical References

• Procollagen
• RNA, Messenger

Topics

• Fibroblasts (metabolism)
• Gene Expression
• Humans
• Hyperpigmentation (metabolism, pathology)
• Leg Dermatoses (metabolism, pathology)
• Male
• Melorheostosis (metabolism)
• Middle Aged
• Procollagen (biosynthesis, genetics)
• RNA, Messenger (genetics)
• Skin (metabolism, pathology)