Abstract | UNLABELLED: The aim of this study was to evaluate prospectively the influence of nutrition on certain factors which may inhibit or promote nephrocalcinosis in two groups of preterm infants, receiving total parenteral nutrition (TPN) and special preterm milk formula respectively, but not furosemide. A total of 37 preterm infants, 15 on TPN and 22 fed a special preterm formula were studied at the end of the 1st, 2nd and 3rd weeks of life, at which time serum and 8 h urine specimens were collected. High ratios of urinary calcium to urinary creatinine (UCa/cr), urinary oxalate to urinary creatinine (Uox/cr) and urinary calcium to urinary citrate (UCa/ cit) indicates an increased risk for nephrocalcinosis while high urinary citrate to urinary creatinine (Ucit/cr) ratio indicates protection. Uox/cr increased significantly (P<0.05) in those infants fed preterm formula, from the end of 2nd week of life and was two-fold higher than in the TPN group of preterm infants (P<0.01). Ucit/cr was higher throughout the study period in the formula fed than in the TPN preterm infants. UCa/ cit was five-fold higher (P<0.01) in the TPN group, by the end of the 3rd week. Urinary calcium and magnesium was similar in both groups during the study period. Two of the infants studied (5.4%), one from each group, developed nephrocalcinosis. CONCLUSION:
|
Authors | Vasilios I Giapros, Athanasios L Papaloukas, Anna S Challa, Panagiotis D Nikolopoulos, Constantine G Tsampoulas, Styliani K Andronikou |
Journal | European journal of pediatrics
(Eur J Pediatr)
Vol. 162
Issue 7-8
Pg. 481-487
(Jul 2003)
ISSN: 0340-6199 [Print] Germany |
PMID | 12750999
(Publication Type: Journal Article)
|
Chemical References |
- Oxalates
- Creatinine
- Magnesium
- Calcium
|
Topics |
- Animals
- Calcium
(urine)
- Creatinine
(urine)
- Humans
- Infant Formula
- Infant, Newborn
- Infant, Premature
- Infant, Premature, Diseases
(urine)
- Kidney Calculi
(urine)
- Magnesium
(urine)
- Milk
- Oxalates
(urine)
- Parenteral Nutrition, Total
|