Abstract | HISTORY AND CLINICAL FINDINGS: A 54-year-old woman was referred for ambulant checkup after an episode of acute renal failure due to severe gastroenteritis and recurrent arthralgias. Physical examination was unremarkable except for the presence of palpable small cervical lymph nodes. INVESTIGATIONS: Serum IgM levels showed a polyclonal increase. All the other routinely examined parameters were within normal limits. Microscopical blood smear examination revealed binucleated lymphocytes. Immunophenotyping of peripheral blood showed a polyclonal B-cell lymphocytosis despite normal numbers of leukocytes and lymphocytes. PCR analysis identified cells with a t(14;18) translocation (bcl-2/IgH rearrangement). DIAGNOSIS: CONCLUSIONS:
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Authors | U Schönermarck, H Diem, P Lohse, W Samtleben |
Journal | Deutsche medizinische Wochenschrift (1946)
(Dtsch Med Wochenschr)
Vol. 128
Issue 20
Pg. 1115-8
(May 16 2003)
ISSN: 0012-0472 [Print] Germany |
Vernacular Title | Persistierende polyklonale B-Zell-Lymphozytose. |
PMID | 12748901
(Publication Type: Case Reports, English Abstract, Journal Article, Review)
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Chemical References |
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Topics |
- Acute Kidney Injury
(etiology)
- Arthralgia
(complications)
- B-Lymphocytes
(classification, pathology)
- Diagnosis, Differential
- Female
- Gastroenteritis
(complications)
- Humans
- Immunoglobulin M
(blood)
- Immunophenotyping
- Lymph Nodes
(pathology)
- Lymphocytosis
(blood, complications, diagnosis)
- Middle Aged
- Polymerase Chain Reaction
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