Successful treatment of recurrent, intractable hyperemesis gravidarum with methylprednisolone. A case report.

Abstract

BACKGROUND:

Severe and persistent hyperemesis gravidarum is a disabling condition. Women may request termination of pregnancy because of the intolerable symptoms and stress.

CASE:

A woman requested termination of pregnancy because of severe hyperemesis gravidarum. Her first three pregnancies were also complicated by severe and persistent vomiting. The vomiting was successfully treated with a short course of methylprednisolone.

CONCLUSION:

Methylprednisolone is an effective treatment for severe hyperemesis gravidarum and should be considered for women whose vomiting is persistent and refractory to conventional therapy.

• Authors: Louis Y Chan, Man Ho Lam, Tze Kin Lau, Robert K H Chin
• Journal: The Journal of reproductive medicine (J Reprod Med) Vol. 48 Issue 4 Pg. 293-5 (Apr 2003) ISSN: 0024-7758 [Print] United States
• PMID: 12746996 (Publication Type: Case Reports, Journal Article)

Chemical References

• Methylprednisolone

Topics

• Adult
• Dose-Response Relationship, Drug
• Drug Administration Schedule
• Female
• Follow-Up Studies
• Humans
• Hyperemesis Gravidarum (diagnosis, drug therapy)
• Methylprednisolone (administration & dosage)
• Pregnancy
• Pregnancy Complications (diagnosis, drug therapy)
• Pregnancy Outcome
• Pregnancy Trimester, First
• Severity of Illness Index