A decreased number of c- kit-expressing cells in a patient with afferent loop syndrome.

Following gastrectomy, stasis in the afferent jejunal loop accompanied by an overgrowth of bacteria leads to a number of clinical symptoms, including the so-called afferent loop syndrome. The disturbances in intestinal motility may be related to stagnation of the intestinal contents in the afferent loop. The pacemaker cells for the basic contractile activity of the intestine are thought to be the interstitial cells of Cajal (ICCs). We and others have reported that ICCs express the c- kit receptor, and that a decreased number of c- kit-expressing ICCs is generally thought to result in disturbed intestinal motility. We report here a patient with postgastrectomy afferent loop syndrome with a decreased number of c- kit-expressing cells in the external muscle layer of the dilated intestine, suggesting damage to the ICCs.
AuthorsTatsuya Kiyohara, Yasuhisa Shinomura, Koji Isozaki, Masanori Nakahara, Shusaku Tsutsui, Hiroyuki Nishibayashi, Yoshiji Miyazaki, Jun-Ichiro Miyagawa, Yuji Matsuzawa
JournalJournal of gastroenterology (J Gastroenterol) Vol. 38 Issue 4 Pg. 390-4 ( 2003) ISSN: 0944-1174 [Print] Japan
PMID12743781 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Barium Sulfate
  • Proto-Oncogene Proteins c-kit
  • Afferent Loop Syndrome (diagnosis, metabolism)
  • Barium Sulfate
  • Endoscopy, Gastrointestinal
  • Gastroenterostomy (adverse effects)
  • Gastrointestinal Motility
  • Humans
  • Intestines (cytology, metabolism)
  • Male
  • Middle Aged
  • Proto-Oncogene Proteins c-kit (metabolism)
  • Reoperation
  • Stomach Ulcer (surgery)

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